ProSci

Death Receptor 6 Recombinant Protein

Product Code:
 
PSI-91-950
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Storage:
 
Lyophilized protein should be stored at -20˚C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7˚C for 2-7 days.
Aliquots of reconstituted samples are stable at -20˚C for 3 months.
 

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PSI-91-950-0.05mg0.05mg£597.00
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This product comes from: United States.
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Further Information

Additional Names:
Tumor necrosis factor receptor superfamily member 21, Death receptor 6, Tnfrsf21, CD358, BM-018, DR6
Application Note:
This recombinant protein can be used for biological assays. For research use only.
Background:
Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
Buffer:
Lyophilized from a 0.2 um filtered solution of PBS,pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Fusion Tag:
C-Fc-6 His tag
NCBI Gene ID #:
94185
NCBI Official Name:
tumor necrosis factor receptor superfamily, member 21
NCBI Official Symbol:
Tnfrsf21
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
64.7 kD
Protein Accession #:
Q9EPU5
Purity:
Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
Human Cells
Swissprot #:
Q9EPU5

Documents