ProSci

IDO Recombinant Protein

Product Code:
 
PSI-90-017
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Storage:
 
Working aliquots are stable for up to 3 months when stored at -20˚C.
 

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PSI-90-017-50ug50ug£801.00
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Further Information

Additional Names:
Indoleamine 2,3-dioxygenase, INDO
Application Note:
This recombinant proteins is for research use only.
Background:
IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.
Biological Activity:
Specific Activity: >100?000U/mg protein with L-tryptophan as substrate. One unit is defined as the amount of enzyme that produces 1nmol of kynurenine per hour.
Buffer:
0.2um-filtered solution in 50mM TRIS-Cl, pH 7.4, containing 1mM EDTA.
Concentration:
1mg/ml
Fusion Tag:
His Tag
NCBI Gene ID #:
15930
NCBI Official Name:
indoleamine 2,3-dioxygenase 1
NCBI Official Symbol:
Ido1
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P28776
Protein GI Number:
123949
Purity:
>90% (SDS-PAGE).

Endotoxin level is less than 1EU/ μg purified protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
Q8K3R4

Documents