ProSci

Flagellin Recombinant Protein

Product Code:
 
PSI-90-279
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Storage:
 
Stable for at least 6 months after receipt when stored at -20˚C.
 

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PSI-90-279-100ug100ug£541.00
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Further Information

Additional Names:
FliC
Application Note:
This recombinant proteins is for research use only.
Background:
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. It activates the innate immune system through the receptor Toll-like Receptor 5 (TLR5) and the intracellular protein NLRC4 (NLR family CARD domain-containing protein 4).
Biological Activity:
Activation of TLR5 in human epithelial cell assays based on NF-kappaB luciferase fusions, on expression of IL-8 (CXCL8), CCL20, inducible nitric oxide synthase, beta-defensin 2 and matrilysin (MMP-7). Maturation of dendritic cells in in vitro and in vivo assays. Adjuvant activity on foreign antigens delivered by subcutaneous and intranasal routes in mice. TLR5 can be stimulated in vitro by Flagellin at a concentration of 5-50ng /ml and in vivo at a starting concentration of 0.1-1ug /mouse.
Buffer:
Contains PBS. Reconstitute with 100 μl sterile water.
Concentration:
1mg/ml after reconstitution.
NCBI Gene ID #:
1253480
NCBI Official Name:
flagellin
NCBI Official Symbol:
fliC
NCBI Organism:
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Physical State:
Lyophilized
Protein Accession #:
P06179
Protein GI Number:
20141325
Purity:
>90% (SDS-PAGE).

Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza).
Source:
Salmonella typhimurium strain 14028
Swissprot #:
P60568

Documents