ProSci

NLRP1/NALP1 Antibody

Product Code:
 
PSI-36-322
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C.
 

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PSI-36-322-100ug100ug£626.00
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Further Information

Additional Names:
NACHT-, LRR- and PYD-containing Protein 1; NLRP1; Caspase Recruitment Domain-containing Protein 7; Death Effector Filament-forming Ced-4-like Apoptosis Protein; Nucleotide-binding Domain and Caspase Recruitment Domain
Application Note:
Western Blot: (1:1,000).
Background:
NALP1/NLRP1 is able to form cytoplasmic structures termed death effector filaments. It enhances and stimulates apoptosis through activation of different caspase cascades. It is involved in the activation of caspase-1 and caspase-5 as part of the NALP1 inflammasome complex which leads to processing and release of IL1B and IL18. Genetic variations in the NLRP1/NALP1 gene are associated with susceptibility to vitiligo-associated multiple autoimmune disease type 1, an autoimmune disorder characterized by the association of vitiligo with several autoimmune and autoinflammatory diseases including autoimmune thyroid disease, rheumatoid arthritis and systemic lupus erythematosus.
Buffer:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Synthetic peptide corresponding to aa 2-25 (A2GGAWGRLACYLEFLKKEELKEFQ25) at the N-terminus of human NLRP1/NALP1.
NCBI Gene ID #:
22861
NCBI Official Name:
NLR family, pyrin domain containing 1
NCBI Official Symbol:
NLRP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
11096303
Protein GI Number:
AAG30288
Research Area:
Innate Immunity
SPECIFICITY:
Recognizes human NLRP1/NALP1. Does not cross-react with mouse NLRP1/NALP1.
Swissprot #:
Q9C000
User NOte:
Optimal dilutions for each application to be determined by the researcher.