ProSci

Progranulin Antibody

Product Code:
 
PSI-36-314
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Guinea Pig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
 
Stable for at least 6 months after receipt when stored at -20˚C.
 

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PSI-36-314-100ug100ug£524.00
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Further Information

Additional Names:
Proepithelin; PEPI; PC Cell-derived Growth Factor
Application Note:
ELISA: (direct and indirect: 1:2,000-1:5,000). Immunohistochemistry: (paraffin sections, 10ug/ml). Western Blot: (1:2,000-1:5,000 using ECL; suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature). Optimal conditions must be determined individually for each application.
Background:
Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer?s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
Buffer:
Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant human progranulin.
NCBI Gene ID #:
2896
NCBI Official Name:
granulin
NCBI Official Symbol:
GRN
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
4504151
Protein GI Number:
NP_002078.1
Research Area:
Cancer,Innate Immunity,Obesity
SPECIFICITY:
Recognizes human progranulin. Detects a band of ~90kDa by Western blot. Weakly cross-reacts with mouse progranulin. Cross-reacts with hGRN-C and hGRN-F.
Swissprot #:
P28799
User NOte:
Optimal dilutions for each application to be determined by the researcher.