ProSci

FLIP Antibody [NF6]

Product Code:
 
PSI-36-162
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
NF6
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunocytochemistry (ICC)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C.
 

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PSI-36-162-100ug100ug£729.00
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Further Information

Additional Names:
I-FLICE; CLARP; CASPER; Usurpin, CASH; FLAME-1
Application Note:
Immunohistochemistry (paraffin sections) . Western Blot (1:1000).
Background:
FLIP is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells and acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. FLIP lacks enzymatic (caspase) activity. FLIP is highly expressed in skeletal muscle, pancreas, heart, kidney, placenta and peripheral blood leukocytes.
Buffer:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant human FLIP (aa 1-480).
NCBI Gene ID #:
8837
NCBI Official Name:
CASP8 and FADD-like apoptosis regulator
NCBI Official Symbol:
CFLAR
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
2253679
Protein GI Number:
AAC51622
Research Area:
Apoptosis,Cancer
SPECIFICITY:
Recognizes short (FLIPS) and long (FLIPL) splice variants of human FLIP.
Swissprot #:
O15519
User NOte:
Optimal dilutions for each application to be determined by the researcher.