Naphthol AS-E phosphate
Product Code:
CDX-N0125
CDX-N0125
Regulatory Status:
RUO
RUO
Shipping:
Ambient
Ambient
Storage:
+4°C
+4°C
No additional charges, what you see is what you pay! *
Code | Size | Price |
---|
CDX-N0125-M500 | 500 mg | £121.00 |
Quantity:
CDX-N0125-G001 | 1 g | £200.00 |
Quantity:
Prices exclude any Taxes / VAT
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: Switzerland.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
- Further Information
- Documents
- References
- Related Products
- Show All
Further Information
Alternate Names/Synonyms:
N-(4-Chlorophenyl)-3-(phosphonooxy)naphthalene-2-carboxamide; KG-501; NASEP
Appearance:
Beige powder.
CAS:
18228-17-6
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.Protect from light and moisture.
InChi:
InChI=1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23)
InChiKey:
RQAQWBFHPMSXKR-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 18228-17-6. Formula: C17H13ClNO5P. MW: 377.72. Synthetic. Histochemical substrate for alkaline phosphatases. Aldolase inhibitor. Small molecule inhibitor. Anticancer compound that directly targets the KIX domain of CBP, resulting in a disrupted CREB-CBP complex, inhibited CREB-target gene induction and inhibited IL-1beta-mediated angiogenic activity in cancer cell lines. Inhibits activity of transcription factor Myb by blocking interaction with KIX domain of coactivator p300 in human leukemia cells. Interferes with the Myb?KIX interaction in vitro and inhibits Myb activity in vivo. Suppresses the expression of Myb target genes and induces myeloid differentiation and apoptosis.
MDL:
MFCD00042718
Molecular Formula:
C17H13ClNO5P
Molecular Weight:
377.72
Package Type:
Vial
Product Description:
Histochemical substrate for alkaline phosphatases. Aldolase inhibitor. Small molecule inhibitor. Anticancer compound that directly targets the KIX domain of CBP, resulting in a disrupted CREB-CBP complex, inhibited CREB-target gene induction and inhibited IL-1beta-mediated angiogenic activity in cancer cell lines. Inhibits activity of transcription factor Myb by blocking interaction with KIX domain of coactivator p300 in human leukemia cells. Interferes with the Myb?KIX interaction in vitro and inhibits Myb activity in vivo. Suppresses the expression of Myb target genes and induces myeloid differentiation and apoptosis.
Purity:
>99% (HPLC)
SMILES:
OP(O)(=O)OC1=CC2=CC=CC=C2C=C1C(=O)NC1=CC=C(Cl)C=C1
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Enzyme Substrates
UNSPSC Number:
41105331
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
Documents
References
(1) Z. Lojda, et al.; Histochemie 11, 13 (1967) | (2) J.L. Best, et al.; PNAS 101, 17622 (2004) | (3) M. St-Jean, et al.; J. Biol. Chem. 282, 14309 (2007) | (4) B.X. Li & X. Xiao, et al.; ChemBioChem 10, 2721 (2009) | (5) J.W. Lee, et al.; PLoS One 10, e0122628 (2015) | (6) S. Uttarkar, et al.; Mol. Cancer Ther. 14, 1276 (2015)
Related Products
Product Name | Product Code | Supplier | Nitrotetrazolium blue chloride | CDX-N0009 | Chemodex | Summary Details | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|