ProSci

Bone proteoglycan II Recombinant Protein

Product Code:
 
PSI-96-234
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-234-0.2mg0.2mg£626.00
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Further Information

Additional Names:
Decorin, DCN, CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Decorin is also known as bone proteoglycan II, PGS2, SLRR1B, DCN, DSPG2 and PG40, is a secreted chondroitin /dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. Decorin and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. Decorin appears to influence fibrillogenesis, and also interacts with fibronectin, thrombospondin, the complement component C1q, epidermal growth factor receptor (EGFR) and transforming growth factor-beta (TGF-beta). Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD).
Background References:
  • Santra, Manoranjan, et al., 2002, J. Biol. Chem. (United States) 277 (38): 35671?81.
  • Iozzo, R V., et al., 1999, J. Biol. Chem. (UNITED STATES) 274 (8): 4489?92.
  • Sch?nherr, E., et al., 1998, Arch. Biochem. Biophys. (UNITED STATES) 355 (2): 241?8.
  • Takeuchi, Y., et al., 1994, J. Biol. Chem. (UNITED STATES) 269 (51): 32634?8.
Biological Activity:
Measured by its ability to modulate collagen fibrillogenesis. At 5 μg/mL, rhDecorin can significantly delay the rate of type I collagen fibrillogenesis.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
1634
NCBI Official Name:
decorin
NCBI Official Symbol:
DCN
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
38.8 kDa
Protein Accession #:
NP_001911.1
Purity:
>90% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P07585

Documents