ProSci

MCAM Recombinant Protein

Product Code:
 
PSI-96-125
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-125-0.1mg0.1mg£765.00
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Further Information

Additional Names:
MCAM, CD146, MUC18
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.
Background References:
  • Kuske MD, et al.,1999, Cytogenet. Cell Genet. 87 (3-4): 258.
  • Elshal MF, et al., 2005, Blood. 106 (8): 2923?4.
  • Elshal MF, et al., 2007, BMC Immunol. 8: 29.
  • Covas DT, et al., 2008, Exp. Hematol. 36 (5): 642?54.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
4162
NCBI Official Name:
melanoma cell adhesion molecule
NCBI Official Symbol:
MCAM
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
61.3 kDa
Protein Accession #:
NP_006491.2
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P43121

Documents