ProSci

CD46 Recombinant Protein

Product Code:
 
PSI-96-123
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-123-0.05mg0.05mg£686.00
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Further Information

Additional Names:
CD46, AHUS2, MCP, MIC10, TLX, TRA2.10
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2).
Background References:
  • Lublin D.M., et al., 1988, J. Exp. Med. 168:181-194.
  • Astier A., et al., 2000, J. Immunol. 164:6091-6095.
  • Noris M., et al., 2003, Lancet 362:1542-1547.
  • Kemper C., et al., 2003, Nature 421:388-392.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
4179
NCBI Official Name:
CD46 molecule, complement regulatory protein
NCBI Official Symbol:
CD46
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
33.6 kDa
Protein Accession #:
AAH30594.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P15529

Documents