ProSci

BCL2L1 Recombinant Protein

Product Code:
 
PSI-96-056
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-056-0.1mg0.1mg£626.00
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Further Information

Additional Names:
BCL2L1, Bcl-XL, Bcl2-L-1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, bcl-xS
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL). BCL2L1 / Bcl-XL is a homodimer protein and belongs to the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a potent inhibitor of cell death. BCL2L1 Inhibits activation of caspases. BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. BCL2L1 / Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Background References:
  • Terrano D.T., et al., 2010, Mol. Cell. Biol. 30:640-656.
  • Wang J., et al., 2011, Cell. Signal. 23:2030-2038.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized human BID protein at 10μg/ml (100μl/well) can bind biotinylated human BCL2L1 protein, The EC50 of biotinylated human BCL2L1 is 6. 5 ng/mL.
Buffer:
20mM HEPES, 50mM KCl, pH 7.5
Fusion Tag:
His Tag
NCBI Gene ID #:
598
NCBI Official Name:
BCL2-like 1
NCBI Official Symbol:
BCL2L1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
24.6 kDa
Protein Accession #:
AAH19307
Purity:
>92% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
Q07817

Documents