ProSci

CD28 Antibody [37.51]

Product Code:
 
PSI-76-741
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Hamster
Antibody Isotype:
 
Golden Syrian Hamster IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
37.51
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Flow Cytometry
  • Functional Study
  • Immunoprecipitation (IP)
Storage:
 
The product should be stored undiluted at 4°C. Do not freeze.
 

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PSI-76-741-1mg1mg£801.00
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Further Information

Additional Names:
CH29-189K17.3, Cd28
Background:
The 37.51 monoclonal antibody specifically reacts with mouse CD28 molecule, a 45 kDa homodimer. It is expressed on most thymocytes, at low density on most of the CD4+ and CD8+ peripheral T lymphocytes, and on the natural killer cells. It is additionally found on activated splenocytes, mast cells, and thymocytes. CD 28 is a costimulator of T lymphocytes and a ligand for CD80 (B7-1), and CD86 (B7-2). The CD28 signaling stimulates the expression of IL-2 and IL-2 receptor and the cytotoxicity of CD3-activated T lymphocytes.The 37.51 antibody stimulates the proliferation of T lymphocytes and natural killer cells and their respective cytokine production.
Background References:
  • Tacke, M., Clark, G. J., Dallman, M. J., Hnig, T. (1995). Cellular distribution and costimulatory function of rat CD28. Regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol ester.The Journal of Immunology,154(10), 5121-5127.
  • Tacke, M., Hanke, G., Hanke, T., Hnig, T. (1997). CD28mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: Evidence for functionally distinct forms of CD28.European journal of immunology,27(1), 239-247.
  • Bluestone, J. A. (1995). New perspectives of CD28-B7-mediated T cell costimulation.Immunity,2(6), 555-559.
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
12487
NCBI Official Name:
CD28 antigen
NCBI Official Symbol:
Cd28
NCBI Organism:
Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/?g of the protein.
Research Area:
Immunology,Functional Assays
SPECIFICITY:
The 37.51 monoclonal antibody specifically reacts with mouse CD28 molecule, a 45 kDa homodimer.
Swissprot #:
P31041
User NOte:
Optimal dilutions for each application to be determined by the researcher.