ProSci

CD4 Antibody [RM4-5] (FITC)

Product Code:
 
PSI-76-372
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rat
Antibody Isotype:
 
Rat IgG2a, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
RM4-5
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Storage:
 
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
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C57BI/6 splenocytes were stained with FITC RM4-5 with relevant isotype control in Red.
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C57BI/6 splenocytes were stained with FITC RM4-5 with relevant isotype control in Red.

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PSI-76-372-0.1mg0.1mg£283.00
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Further Information

Additional Names:
L3T4, Ly-4, Cd4
Background:
The RM4-5 monoclonal antibody specifically reacts with mouse CD4, also known as L3T4, a 55 kDa differentiation antigen expressed by the majority of thymocytes, subpopulations of mature T cells (like major histocompatibility complex class II-restricted T lymphocytes), a subset of natural killer T cells, and on pluripotent hematopoietic stem cells. CD4 binds to the major histocompatibility complex class II (MHC class II) and enhances T lymphocyte development and mature T cells functions. In T lymphocytes, CD4 binds to the cytoplasmic tail of enzyme tyrosine kinase (p56lck).Binding of RM4-5 is blocked by the anti-mouse CD4 clone GK1.5.
Background References:
  • Shevach, E. M. (2000). Regulatory T cells in autoimmmunity*.Annual review of immunology,18(1), 423-449.
  • Wu, L., Scollay, R., Egerton, M., Pearse, M., Spangrude, G. J., Shortman, K. (1991). CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus.
  • Bliss, S. K., Bliss, S. P., Beiting, D. P., Alcaraz, A., Appleton, J. A. (2007). IL-10 regulates movement of intestinally derived CD4+ T cells to the liver.The Journal of Immunology,178(12), 7974-7983.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
FITC
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
12504
NCBI Official Name:
CD4 antigen
NCBI Official Symbol:
Cd4
NCBI Organism:
Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Immunology
SPECIFICITY:
The RM4-5 monoclonal antibody specifically reacts with mouse CD4, also known as L3T4, a 55 kDa differentiation antigen expressed by the majority of thymocytes, subpopulations of mature T cells (like major histocompatibility complex class II-restricted T lymphocytes), a subset of natural killer T cells, and on pluripotent hematopoietic stem cells.
Swissprot #:
P06332
User NOte:
Optimal dilutions for each application to be determined by the researcher.