ProSci

CD25 Antibody [PC61.5] (FITC)

Product Code:
 
PSI-76-512
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rat
Antibody Isotype:
 
Rat IgG1, lambda
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
PC61.5
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Storage:
 
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
 

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CodeSizePrice
PSI-76-512-0.025mg0.025mg£264.00
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Further Information

Additional Names:
CD25, Il2r, Ly-43, Il2ra
Background:
The PC61.5 antibody specifically reacts with mouse CD25, the 55 kDa low-affinity Interleukin-2 Receptor alpha chain (IL-2R alpha), expressed on early progenitors of T and B lineage, and on B and T cells. Together with CD122 (IL-2 Receptor beta) and CD 132 (IL-2 Receptor gammac, the common gamma chain), CD25 forms high-affinity receptor complexes for IL-2. Resting B and T cells and natural killer cells do not express IL-2Ralpha. Cd25 is also expressed on the dendritic cells, and it enhances lymphocyte differentiation and activation.The PC61.5 antibody block the binding of IL-2 to both high-affinity and low-affinity receptors.
Background References:
  • Hayashi, T., Hasegawa, K., Adachi, C. (2005). Elimination of CD4+ CD25+ T cell accelerates the development of glomerulonephritis during the preactive phase in autoimmune-prone female NZBx NZW F1 mice. International journal of experimental pathology,86(5), 289-296.
  • Lowenthal, J. W., Tougne, C., MacDonald, H. R., Smith, K. A., Nabholz, M. (1985). Antigenic stimulation regulates the expression of IL 2 receptors in a cytolytic T lymphocyte clone.The Journal of Immunology,134(2), 931-939.
  • Huang, B., Zhao, J., Shen, S., Li, H., He, K. L., Shen, G. X., ... Feng, Z. H. (2007). Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling.Cancer Research,67(9), 4346-4352.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
FITC
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
16184
NCBI Official Name:
interleukin 2 receptor, alpha chain
NCBI Official Symbol:
Il2ra
NCBI Organism:
Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Immunology
SPECIFICITY:
The PC61.5 antibody specifically reacts with mouse CD25, the 55 kDa low-affinity Interleukin-2 Receptor alpha chain (IL-2R alpha), expressed on early progenitors of T and B lineage, and on B and T cells.
Swissprot #:
P01590
User NOte:
Optimal dilutions for each application to be determined by the researcher.