ProSci

CD8a Antibody [2.43] (APC)

Product Code:
 
PSI-76-658
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rat
Antibody Isotype:
 
Rat IgG2b
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
2.43
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Storage:
 
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
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C57Bl/6 splenonocytes were stained with APC 17A2 and the corresponding isotype controls are in red.
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C57Bl/6 splenonocytes were stained with APC 17A2 and the corresponding isotype controls are in red.

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PSI-76-658-0.025mg0.025mg£307.00
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Further Information

Additional Names:
Ly-2, Ly-B, Ly-35, Lyt-2, BB154331, Cd8a
Background:
The 2.43 monoclonal antibody specifically reacts with mouse CD8 antigen. CD8a (the alpha chains) form heterodimers with CD8b (the beta chains) or homodimers (alpha-alpha), which occur as receptors on the surface of the majority of thymocytes. A subpopulation of mature T lymphocytes expresses the CD8 alpha beta (alpha beta TCR T cells), and a subpopulation of intestinal intraepithelial lymphocytes and dendritic cells express CD8a without CD8b. CD8 interacts with the mouse major histocompatibility complex class I (MHC class I) molecules on antigen-presenting cells or epithelial cells.
Background References:
  • Sayos, J., Wu, C., Morra, M., Wang, N., Zhang, X., Allen, D., ... Terhorst, C. (1998). The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM.Nature,395(6701), 462-469.
  • Thomas, Y., Sosman, J., Irigoyen, O., Friedman, S. M., Kung, P. C., Goldstein, G., Chess, L. (1980). Functional analysis of human T cell subsets defined by monoclonal antibodies. I. Collaborative TT interactions in the immunoregulation of B cell differentiation.The Journal of Immunology,125(6), 2402-2408.
  • Campanelli, R., Palermo, B., Garbelli, S., Mantovani, S., Lucchi, P., Necker, A., ... Giachino, C. (2002). Human CD8 coreceptor is strictly involved in MHCpeptide tetramerTCR binding and T cell activation.International immunology,14(1), 39-44.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
APC
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
12525
NCBI Official Name:
CD8 antigen, alpha chain
NCBI Official Symbol:
Cd8a
NCBI Organism:
Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Immunology
SPECIFICITY:
The 2.43 monoclonal antibody specifically reacts with mouse CD8 antigen.
Swissprot #:
P01731
User NOte:
Optimal dilutions for each application to be determined by the researcher.