ProSci

SREBP-1 (phospho Ser439) Antibody

Product Code:
 
PSI-80-001
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Rat
Application:
 
Western Blot (WB)
Storage:
 
Store antibody at -20°C for up to one year.
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Western blot analysis of extracts from Jurkat cells treated with TNF using Phospho-SREBP-1 (Ser439) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Western blot analysis of extracts from Jurkat cells treated with TNF using Phospho-SREBP-1 (Ser439) Antibody. The lane on the right is treated with the antigen-specific peptide.

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PSI-80-001-0.1mg0.1mg£488.00
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Further Information

Additional Names:
SRBP1, SREBF1, SREBP1, sterol regulatory element-binding protein 1,
Application Note:
Western Blot: 1:500~1:1000
Background:
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway By similarity. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').
Background References:
  • Bengoechea-Alonso MT, Ericsson J (2006) Cell Cycle 5, 1708-18
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SREBP-1 (phospho Ser439) antibody was raised against a peptide sequence around phosphorylation site of serine439 (Q-S-S (p)-P-L) derived from Human SREBP-1 .
Modifications:
Phospho-Specific
NCBI Gene ID #:
6720
NCBI Official Name:
sterol regulatory element binding transcription factor 1
NCBI Official Symbol:
SREBF1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
122 kDa
Protein Accession #:
NP_001005291.1
Protein GI Number:
52630419
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of SREBP-1 only when phosphorylated at serine 439.
Swissprot #:
P36956