ProSci

Gab2 (phospho Tyr643) Antibody

Product Code:
 
PSI-79-912
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
 
Store antibody at -20°C for up to one year.
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Western blot analysis of extracts from 3T3 cells (Lane 2), using Gab2 (Phospho-Tyr643) Antibody. The lane on the left is treated with antigen-specific peptide.
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Immunohistochemical analysis of paraffin-embedded human brain tissue using Gab2 (Phospho-Tyr643) antibody (left) or the same antibody preincubated with blocking peptide (right).
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Western blot analysis of extracts from 3T3 cells (Lane 2), using Gab2 (Phospho-Tyr643) Antibody. The lane on the left is treated with antigen-specific peptide.
Immunohistochemical analysis of paraffin-embedded human brain tissue using Gab2 (Phospho-Tyr643) antibody (left) or the same antibody preincubated with blocking peptide (right).

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PSI-79-912-0.1mg0.1mg£488.00
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Further Information

Additional Names:
pp100, GABJ, KIAA0571
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background:
This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
Background References:
  • Nishida K., Blood 93:1809-1816(1999).
  • Nagase T., DNA Res. 5:31-39(1998).
  • Salomon A.R., Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Gab2 (phospho Tyr643) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 643 (V-D-Y (p)-V-Q) derived from Human Gab2 .
Modifications:
Phospho-Specific
NCBI Gene ID #:
9846
NCBI Official Name:
GRB2-associated binding protein 2
NCBI Official Symbol:
GAB2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
74 kDa
Protein Accession #:
NP_536739.1
Protein GI Number:
18105042
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of Gab2 only when phosphorylated at tyrosine 643.
Swissprot #:
Q9UQC2