Further Information
CDK5, CRK6, Cell division protein kinase 5, Tau protein kinase II catalytic subunit, kinase Cdk5
Western Blot: 1:500~1:1000
Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM.
- Miao Y, et al. (2012)PLoS One 7, e42318. Li P, et al. (2011)Cell 147, 815-26. Nohara A, et al. (2011)J Biol Chem 286, 33457-65.
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
CDK5 (phospho Tyr15) antibody was raised against a peptide sequence around phosphorylation site of Tyrosine15 (G-T-Y (p)-G-T) derived from Human CDK5.
Phospho-Specific
1020
cyclin-dependent kinase 5
CDK5
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
33 kDa
NP_001157882.1
4826675
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Phospho-Specific
The antibody detects endogenous level of CDK5 only when phosphorylated at tyrosine 15.
Q00535