ProSci

HER2 (phospho Tyr1112) Antibody

Product Code:
 
PSI-79-955
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Storage:
 
Store antibody at -20°C for up to one year.
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Western blot analysis of extracts from HepG2 tissue using HER2 (Phospho-Tyr1112) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Western blot analysis of extracts from HepG2 tissue using HER2 (Phospho-Tyr1112) Antibody. The lane on the right is treated with the antigen-specific peptide.

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PSI-79-955-0.1mg0.1mg£488.00
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Further Information

Additional Names:
C-erbB-2, NGL, NEU proto-oncogene, MLN 19,
Application Note:
Western Blot: 1:500~1:1000
Background:
Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.
Background References:
  • Chuang TD, et al. (2010)J Biol Chem 285, 23598-606
  • Bhuvaneswari R, Gan YY, Soo KC, Olivo M (2009) Mol Cancer 8, 94
  • Thelemann A, et al. (2005) Mol Cell Proteomics 4, 356-76
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
HER2 (phospho Tyr1112) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1112 (Q-R-Y (p)-S-E) derived from Human HER2.
Modifications:
Phospho-Specific
NCBI Gene ID #:
2064
NCBI Official Name:
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
NCBI Official Symbol:
ERBB2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
150 kDa
Protein Accession #:
NP_001005862.1
Protein GI Number:
54792098
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of HER2 only when phosphorylated at tyrosine 1112.
Swissprot #:
P04626