ProSci

CD284 Antibody [HTA125] (PE)

Product Code:
 
PSI-76-964
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG2a, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
HTA125
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Storage:
 
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
 

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PSI-76-964-100tests100tests£601.00
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Further Information

Additional Names:
TOLL, CD284, TLR-4, ARMD10, TLR4
Background:
The HTA125 monoclonal antibody specifically reacts with human CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4). CD284 is an important molecule in the innate immunity response to bacterial lipoproteins. It is expressed by monocytes, macrophages, and endothelial cells. The HTA125 antibody can block Lipopolysaccharide-induced cytokine production and immunoprecipitate human TLR4.
Background References:
  • Yang, D., Liu, Y., Chen, Y., Jiao, D., Hou, X., Wang, L., Fu, N. (2012). Pretreatment with Mycobacterium avium-derived lipids attenuates the response of murine macrophages to components of Mycobacterium tuberculosis.International journal of molecular medicine,29(6), 1072.
  • Nomura, F., Akashi, S., Sakao, Y., Sato, S., Kawai, T., Matsumoto, M., ... Akira, S. (2000). Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression.The Journal of Immunology,164(7), 3476-3479.
  • Sato, S., Nomura, F., Kawai, T., Takeuchi, O., Mhlradt, P. F., Takeda, K., Akira, S. (2000). Synergy and cross-tolerance between toll-like receptor (TLR) 2-and TLR4-mediated signaling pathways.The Journal of Immunology,165(12), 7096-7101.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
PE
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
7099
NCBI Official Name:
toll-like receptor 4
NCBI Official Symbol:
TLR4
NCBI Organism:
Homo sapiens
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Innate Immunity
SPECIFICITY:
The HTA125 monoclonal antibody specifically reacts with human CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4).
Swissprot #:
O00206
User NOte:
Optimal dilutions for each application to be determined by the researcher.