ProSci

CD144 Antibody [16B1] (PE)

Product Code:
 
PSI-76-861
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
16B1
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Storage:
 
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
 

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PSI-76-861-0.1mg0.1mg£662.00
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Further Information

Additional Names:
7B4, CD144, CDH5
Background:
The 16B1 monoclonal antibody specifically reacts with human CD144, the 140 kDA molecule called vascular endothelial (VE-cadherin) or cadherin 5. CD144 is an endothelial specific calcium-dependent adhesion molecule involved in cell contact-dependent growth inhibition, migration, survival, adhesion. It is concentrated at the intercellular boundaries of endothelial cells and essential in maintaining cell layer integrity.
Background References:
  • Corada, M., Mariotti, M., Thurston, G., Smith, K., Kunkel, R., Brockhaus, M., ... Dejana, E. (1999). Vascular endothelialcadherin is an important determinant of microvascular integrity in vivo.Proceedings of the National Academy of Sciences,96(17), 9815-9820.
  • Crosby, C. V., Fleming, P. A., Argraves, W. S., Corada, M., Zanetta, L., Dejana, E., Drake, C. J. (2005). VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly.Blood,105(7), 2771-2776.
  • May, C., Doody, J. F., Abdullah, R., Balderes, P., Xu, X., Chen, C. P., ... Bohlen, P. (2005). Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature.Blood,105(11), 4337-4344.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
PE
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
1003
NCBI Official Name:
cadherin 5, type 2 (vascular endothelium)
NCBI Official Symbol:
CDH5
NCBI Organism:
Homo sapiens
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Cancer
SPECIFICITY:
The 16B1 monoclonal antibody specifically reacts with human CD144, the 140 kDA molecule called vascular endothelial (VE-cadherin) or cadherin 5.
Swissprot #:
P33151
User NOte:
Optimal dilutions for each application to be determined by the researcher.