ProSci

CD40 Antibody [5C3] (FITC)

Product Code:
 
PSI-76-021
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
5C3
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Storage:
 
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
 

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PSI-76-021-100tests100tests£469.00
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Further Information

Additional Names:
p50, Bp50, CDW40, TNFRSF5, CD40
Background:
The 5C3 monoclonal antibody specifically reacts with human CD40, a 48kDA type I glycoprotein. CD40 is part of the TNFR family and expressed on a subset of T cells, B cells, dendritic cells, and macrophages. It has been shown to be involved in the protection of B cells from apoptosis, B cell differentiation, co-stimulation, and isotype class-switching. The 5C3 antibody partially blocks the binding of CD40L (CD154). In the presence of IL-4 or PMA, the 5C3 antibody promotes B cell proliferation.
Background References:
  • Schlossman, S. F. (1995).Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.
  • Barclay, A. N., Birkeland, M. L., Brown, M. H., Beyers, A. D., David, S. J., Somoza, C., Williams, A. F. The Leukocyte Antigen Facts Book. 1993.Academic Prss, London.
  • Challa, A., Pound, J. D., Gordon, J., Armitage, R. J. (1999). Epitopedependent synergism and antagonism between CD40 antibodies and soluble CD40 ligand for the regulation of CD23 expression and IgE synthesis in human B cells.Allergy,54(6), 576-583.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
FITC
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
958
NCBI Official Name:
CD40 molecule, TNF receptor superfamily member 5
NCBI Official Symbol:
CD40
NCBI Organism:
Homo sapiens
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Immunology
SPECIFICITY:
The 5C3 monoclonal antibody specifically reacts with human CD40, a 48kDA type I glycoprotein.
Swissprot #:
P25942
User NOte:
Optimal dilutions for each application to be determined by the researcher.