ProSci

MANF Recombinant Protein

Product Code:
 
PSI-40-563
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized MANF recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted MANF stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing M
 

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CodeSizePrice
PSI-40-563-0.005mg0.005mg£300.00
Quantity:
PSI-40-563-0.025mg0.025mg£428.00
Quantity:
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This product comes from: United States.
Typical lead time: 14-21 working days.
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Further Information

Additional Names:
ARP, ARMET, ARP, Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein
Background:
MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. MANF and its structural homolog CDNF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Recombinant human MANF is an 18.1 kDa protein consisting of 158 amino acids including 8 cysteine residues.
Biological Activity:
Biological activity was determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 μg/mL. Endotoxin level is less than 0.1 ng per μg (1EU/μg).
NCBI Gene ID #:
7873
NCBI Official Name:
mesencephalic astrocyte-derived neurotrophic factor
NCBI Official Symbol:
MANF
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_006001.3
Protein GI Number:
299523086
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P55145

Documents