AdipoGen Life Sciences

Apcin

Product Code:
 
AG-CR1-3603
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
-20°C
Storage:
 
-20°C
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Chemical Structure
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Chemical Structure

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AG-CR1-3603-M0055 mg£90.00
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AG-CR1-3603-M02525 mg£300.00
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Further Information

Alternate Names/Synonyms:
Anaphase Promoting Complex Inhibitor
Appearance:
White to off-white solid.
CAS:
300815-04-7
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Avoid freeze/thaw cycles.
InChi:
InChI=1S/C13H14Cl3N7O4/c1-8-19-7-9(23(25)26)22(8)5-6-27-12(24)21-10(13(14,15)16)20-11-17-3-2-4-18-11/h2-4,7,10H,5-6H2,1H3,(H,21,24)(H,17,18,20)
InChiKey:
ZEXHXVOGJFGTRX-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 300815-04-7. Formula: C13H14Cl3N7O4. MW: 438.7. Cell permeable compound capable of slowing anaphase-promoting complex/cyclosome (APC/C)-dependent proteolysis. Inhibitor of the ubiquitin ligase activity of the APC/C by inhibiting substrate binding to Cdc20. Distinct mechanism of action than proTAME. Blocks mitotic exit only modestly when used alone in cultured cells. A strong synergistic effect is observed when Apcin and proTAME are used simultaneously, providing a more robust mitotic arrest. This may be very beneficial when treating cells that do not efficiently convert proTAME to its active parent compound (TAME) or if experiments demand strong APC/C inhibition.
MDL:
MFCD00525727
Molecular Formula:
C13H14Cl3N7O4
Molecular Weight:
438.7
Package Type:
Vial
Product Description:
Cell permeable compound capable of slowing anaphase-promoting complex/cyclosome (APC/C)-dependent proteolysis. Inhibitor of the ubiquitin ligase activity of the APC/C by inhibiting substrate binding to Cdc20. Distinct mechanism of action than proTAME. Blocks mitotic exit only modestly when used alone in cultured cells. A strong synergistic effect is observed when Apcin and proTAME are used simultaneously, providing a more robust mitotic arrest. This may be very beneficial when treating cells that do not efficiently convert proTAME to its active parent compound (TAME) or if experiments demand strong APC/C inhibition.
Purity:
>98% (HPLC)
SMILES:
CC1=NC=C(N1CCOC(=O)NC(NC1=NC=CC=N1)C(Cl)(Cl)Cl)[N+]([O-])=O
Solubility Chemicals:
Soluble in DMSO (20mM).
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.

References

Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C: K.L. Sackton, et al.; Nature 514, 646 (2014)