AdipoGen Life Sciences

Z-Leu-Leu-Nva-CHO [MG-115]

Product Code:
 
AG-CP3-0015
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
-20°C
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Chemical Structure
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Chemical Structure

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AG-CP3-0015-M0011 mg£30.00
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AG-CP3-0015-M0055 mg£75.00
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Further Information

Alternate Names/Synonyms:
Z-LLNva-CHO; Proteasome Inhibitor
Appearance:
Solid lyophilized powder.
CAS:
133407-86-0
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.
InChi:
InChI=1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1
InChiKey:
QEJRGURBLQWEOU-FKBYEOEOSA-N
Long Description:
Chemical. CAS: 133407-86-0. Formula: C25H39N3O5. MW: 461.6. Potent, reversible and cell permeable proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome. Calpain and cathepsin inhibitor. Apoptosis inducer in Rat-1 and PC12 cells via a p53-dependent pathway. Autophagy activator.
MDL:
MFCD00671410
Molecular Formula:
C25H39N3O5
Molecular Weight:
461.6
Other data:
Use: Add from DMSO stock directly to in vitro or in vivo assays at desired concentration. Pre-incubation with compound prior to assay is recommended for maximal effect.
Package Type:
Vial
Product Description:
Potent, reversible and cell permeable proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome. Calpain and cathepsin inhibitor. Apoptosis inducer in Rat-1 and PC12 cells via a p53-dependent pathway. Autophagy activator.
Purity:
>95% (HPLC)
Sequence:
Z-Leu-Leu-Nva-aldehyde
SMILES:
[H]C(=O)[C@H](CCC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids: J. Adams, et al.; Bioorg. Med. Chem. Lett. 17, 333 (1998) | Ubiquitination of E3 ubiquitin ligase TRIM5 alpha and its potential role: K. Yamauchi, et al.; FEBS J. 275, 1540 (2008) | Proteasome inhibition induces stress kinase dependent transport deficits-implications for Alzheimer's disease: L. Agholme, et al.; Mol. Cell Neurosci. 58, 29 (2014)