Chemodex

Difluoromethyl phenyl sulfone

Product Code:
 
CDX-D0401
Product Group:
 
Other Biochemicals
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
AMBIENT
Storage:
 
-20°C
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Chemical Structure
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Chemical Structure

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CDX-D0401-GG252.5 g£102.00
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CDX-D0401-G01010 g£280.00
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Further Information

Alternate Names/Synonyms:
Phenyl difluoromethyl sulfone
Appearance:
Colorless to light yellow semi-solid or solid.
CAS:
1535-65-5
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry.Protect from light and moisture.
Hazards:
H315, H319, H335
InChi:
InChI=1S/C7H6F2O2S/c8-7(9)12(10,11)6-4-2-1-3-5-6/h1-5,7H
InChiKey:
LRHDNAVPELLXDL-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1535-65-5. Formula: C7H6F2O2S. MW: 192.2. Synthetic. Building block for synthesis. Has been used for nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls, reductive silylation and the preparation of trifluoro- and difluoromethylsilanes, fluoroalkylation/chloroalkylation of alpha,beta-enones, arynes, acetylenic ketones and other Michael acceptors and difluoromethylation of primary alkyl halides . It is also used in preparation of alpha-difluoromethyl amines, anti-difluoropropanediols, beta-difluoromethylated and beta-difluoromethylenated alcohols and amines, difluoroalkenes, difluoromethyl alcohol derivatives and fluoromethylated vicinal ethylenediamines.
MDL:
MFCD01050170
Molecular Formula:
C7H6F2O2S
Molecular Weight:
192.2
Package Type:
Vial
Precautions:
P261, P305, P351, P338
Product Description:
Building block for synthesis. Has been used for nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls, reductive silylation and the preparation of trifluoro- and difluoromethylsilanes, fluoroalkylation/chloroalkylation of alpha,beta-enones, arynes, acetylenic ketones and other Michael acceptors and difluoromethylation of primary alkyl halides . It is also used in preparation of alpha-difluoromethyl amines, anti-difluoropropanediols, beta-difluoromethylated and beta-difluoromethylenated alcohols and amines, difluoroalkenes, difluoromethyl alcohol derivatives and fluoromethylated vicinal ethylenediamines.
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
FC(F)S(=O)(=O)C1=CC=CC=C1
Solubility Chemicals:
Soluble in chloroform.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

(1) G.K.S. Prakash, et al.; J. Org. Chem. 68, 4457 (2003) | (2) G.K.S. Prakash, et al.; Angew. Chem. 42, 5216 (2003) | (3) G.K.S. Prakash, et al.; Angew. Chem. 43, 5203 (2004) | (4) G.K.S. Prakash, et al.; Org. Lett. 6, 4315 (2004) | (5) Y. Li & J. Hu; Angew. Chem. 44, 5882 (2005) | (6) G.K.S. Prakash, et al.; Europ. J. Org. Chem. 11, 2218 (2005) | (7) C. Ni, et al.; Angew. Chem. 46, 786 (2007) | (8) J. Liu, et al.; J. Org. Chem. 72, 3119 (2007) | (9) C. Ni, et al.; J. Org. Chem. 73, 5699 (2008) | (10) M. Hu, et al.; J. Fluor. Chem. 155, 52 (2013)