ProSci

PDCL2 Antibody

Product Code:
 
PSI-7887
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Antibody Clone:
 
51944950
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
PDCL2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
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Western blot analysis of PDCL2 in rat liver tissue lysate with PDCL2 antibody at 1 μg/ml.
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Western blot analysis of PDCL2 in rat liver tissue lysate with PDCL2 antibody at 1 μg/ml.

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CodeSizePrice
PSI-7887-0.02mg0.02mg£150.00
Quantity:
PSI-7887-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
PDCL2 Antibody: GCPHLP, Phosducin-like protein 2
Application Note:
PDCL2 antibody can be used for detection of PDCL2 by Western blot at 1 - 2 μg/ml.

Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Background:
Phosducin-like proteins (PhLPs) are a conserved family of proteins with thioredoxin-like domains that were initially identified as modulators of G protein signaling (1,2). PDCL2 is highly homologous to PDCL and shares an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain (3). PDCL2 has been shown to interact with the chaperonin CCT and is essential for cytoskeletal protein function and cell cycle progression (4).
Background References:
  • Miles MF, Barhite S, Sganga M, et al. Phosducin-like protein: an ethanol-responsive potential modulator of guanine nucleotide-binding protein function. Proc. Natl. Acad. Sci. USA 1993; 90:10831-5.
  • Ruiz-Gomez A, Humrich J, Murga C, et al. Phosphorylation of phosducin and phosducinlike protein by G protein-coupled receptor kinase 2. J. Biol. Chem. 2000; 275:29724-30.
  • Lou X, Bao R, Zhou CZ, et al. Structure of the thioredoxin-fold domain of human phosducin-like protein 2. Acta Crystallographica 2009; F65:67-70.
  • Stirling PC, Srayko M, Takhar KS, et al. Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeltal protein function and cell cycle progrssion. Mol. Biol. Cell 2007; 18:2336-45.
Buffer:
PDCL2 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
PDCL2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human PDCL2.

The immunogen is located within the last 50 amino acids of PDCL2.
NCBI Gene ID #:
132954
NCBI Official Name:
phosducin-like 2
NCBI Official Symbol:
PDCL2
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 27 kDa

Observed: 25 kDa
Protein Accession #:
NP_689614
Protein GI Number:
51944950
Purification:
PDCL2 antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
SPECIFICITY:
PDCL2 antibody is human, mouse and rat reactive. PDCL2 antibody is predicted to not cross-react with other members of the PDCL protein family.
Swissprot #:
Q8N4E4
User NOte:
Optimal dilutions for each application to be determined by the researcher.