Further Information
Gap junction beta-2 protein, connexin 26, CX26, DFNA3, DFNA3A, DFNB1, DFNB1A, HID, KID, NSRD1, PPK
GJB2 antibody can be used for detection of GJB2 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
The Gap junction beta-2 protein (GJB2), also known as Connexin 26, is member of the gap junction protein family which form structures that were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells (1). Mutations in the GJB2 gene are thought to be responsible for as much as 35-45% of congenital sensorineural hearing loss in some populations (2). Other mutations in this gene have also been linked to a wide array of skin diseases (3).
- Zhou JZ and Jiang JX. Gap junctions and hemichannel-independent actions of connexins on cell and tissue functions ? An update. FEBS Lett. 2014; 588:1186-92.
- Petit C, Levilliers J, and Hardelin JP. Molecular genetics of hearing loss. Annu. Rev. Genet. 2001; 35:589-646.
- Gerido DA and White TW. Connexin disorders of the ear, skin, and lens. Biochim. Biophys. Acta. 2004; 1662:159-70.
GJB2 antibody is supplied in PBS containing 0.02% sodium azide.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Rat: (94%), Mouse: (94%), Sheep: (88%), Bovine: (88%), Chicken: (82%)
GJB2 antibody was raised against a 16 amino acid peptide near the center of human GJB2.
The immunogen is located within amino acids 80 - 130 of GJB2.
2706
gap junction protein, beta 2, 26kDa
GJB2
homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 25 kDa
Observed: 26 kDa
NP_003995
42558283
GJB2 antibody is affinity chromatography purified via peptide column.
Homeostasis
GJB2 antibody is human specific.
P29033
Optimal dilutions for each application to be determined by the researcher.