AdipoGen Life Sciences

anti-IL-1alpha (p18) (mouse) mAb (Teo-1)

Product Code:
 
AG-20B-0064
Product Group:
 
Primary Antibodies
Antibody Isotype:
 
Mouse IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
Teo-1
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
-20°C
Storage:
 
-20°C
1 / 1
Mouse IL-1alpha (full-length p30 and cleaved p18 fragments) are detected by immunoblotting using anti-IL-1alpha (p18) (mouse), mAb (Teo-1) (Prod. No AG-20B-0064). Method: IL-1alpha was analyzed by Western blot in cell extracts of bone m
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Mouse IL-1alpha (full-length p30 and cleaved p18 fragments) are detected by immunoblotting using anti-IL-1alpha (p18) (mouse), mAb (Teo-1) (Prod. No AG-20B-0064). Method: IL-1alpha was analyzed by Western blot in cell extracts of bone m

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Further Information

Alternate Names/Synonyms:
Interleukin-1alpha IL-1alpha
Concentration:
1mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Recombinant mouse mature IL-1alpha.
Long Description:
Monoclonal Antibody. Recognizes mouse IL-1alpha p18 cleaved and full-length fragments. Isotype: Mouse IgG. Clone: Teo-1. Applications: ELISA, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
NCBI, Uniprot Number:
P01582
Package Type:
Plastic Vial
Product Description:
The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
Purity:
>95% (SDS-PAGE)
Source / Host:
Purified from concentrated hybridoma tissue culture supernatant.
Specificity:
Recognizes mouse IL-1alpha p18 cleaved and full-length fragments.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.

References

Formyl peptide receptor 1 signaling potentiates inflammatory brain injury: Z. Li, et al.; Sci. Transl. Med. 13, 605 (2021)