ProSci

Protocadherin X Antibody

Product Code:
 
PSI-42-252
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Caprine (Goat)
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Aliquot and store at -20˚C. Minimize freezing and thawing.
 

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PSI-42-252-0.1mg0.1mg£565.00
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Further Information

Additional Names:
PCDH11Y, protocadherin 11 Y-linked, PCDH-PC, PCDH11X, PCDH22, PCDHY, OTTHUMP00000033077, protocadherin 11 X-linked, protocadherin 22, protocadherin Y, RP13-138P15.1, PCDH-X, PCDH11, PCDHX, protocadherin 11X, protocadherin X, protocadherin-S
Application Note:
Peptide ELISA: antibody detection limit dilution 1:8000.Western Blot:Preliminary experiments gave an approx 75kDa band in Human Brain (Amygdala, Hippocampus, Substantia nigra) lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 115kDa according to NP_116753.1 and of 113kDa according to NP_055337.1, the smallest reported isoforms. The 75kDa band was successfully blocked by incubation with the immunizing peptide. We would appreciate any feedback from people in the field - have any results been reported with other antibodies/lysates? Have any further splice variants/modified forms been reported?
Background References:
  • Kalmady SV, Venkatasubramanian G, Evidence for positive selection on Protocadherin Y gene in Homo sapiens: implications for schizophrenia. Schizophrenia research 2009 Mar 108 (1-3): 299-300.
Buffer:
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20?C. Minimize freezing and thawing.
Concentration:
500 ug/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Expected Species Reactivity based on sequence homology: Human
Immunogen:
The immunogen for this antibody is: C-KYNWVTTPTTFK
NCBI Gene ID #:
83259; 27328
NCBI Official Name:
protocadherin 11 Y-linked
NCBI Official Symbol:
PCDH11Y
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_116753.1, NP_116754.1, NP_116755.1, NP_055337.1, NP_055337.1, NP_116750.1, NP_116751.1
Protein GI Number:
14589942
Purification:
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Research Area:
Signal Transduction ,Neuroscience
SPECIFICITY:
This antibody is expected to recognize all reported Y-linked isoforms (NP_116753.1; NP_116754.1; NP_116755.1) and all reported X-linked isoforms (NP_055337.1; NP_055337.1; NP_116750.1; NP_116751.1).
Swissprot #:
Q9BZA8