ProSci

HMBS Antibody

Product Code:
 
PSI-26-873
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
For short periods of storage (days) store at 4˚C. For longer periods of storage, store HMBS antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
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Antibody used in WB on Human Liver at 0.2-1 ug/ml.
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Antibody used in WB on Human Liver at 0.2-1 ug/ml.

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PSI-26-873-100ul100ul£662.00
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This product comes from: United States.
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Further Information

Additional Names:
HMBS, PBG-D, PBGD, UPS, PORC
Application Note:
HMBS antibody can be used for detection of HMBS by ELISA at 1:312500. HMBS antibody can be used for detection of HMBS by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Background:
HMBS is a member of the hydroxymethylbilane synthase superfamily. It is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria.This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described.
Background References:
  • Kuo, H.C., J. Neurol. Sci. 260 (1-2), 231-235 (2007).
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human HMBS.
NCBI Gene ID #:
3145
NCBI Official Name:
hydroxymethylbilane synthase
NCBI Official Symbol:
HMBS
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
40 kDa
Protein Accession #:
NP_000181
Protein GI Number:
20149500
Purification:
Antibody is purified by peptide affinity chromatography method.
Swissprot #:
P08397
User NOte:
Optimal dilutions for each application to be determined by the researcher.