Further Information
ADAMTS4, ADAMTS-2, ADAMTS-4, ADMP-1, KIAA0688
ADAMTS4 antibody can be used for detection of ADAMTS4 by ELISA at 1:62500. ADAMTS4 antibody can be used for detection of ADAMTS4 by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
ADAMTS4 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. ADAMTS4 lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
batch dependent
Unconjugated
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ADAMTS4.
9507
ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADAMTS4
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
37 kDa, 90 kDa
AAH30812
21410063
Antibody is purified by peptide affinity chromatography method.
Membrane ,Signal Transduction
Q8NEK2
Optimal dilutions for each application to be determined by the researcher.
