Further Information
TNFSF12, APO3L, DR3LG, MGC129581, MGC20669, TWEAK
TNFSF12 antibody can be used for detection of TNFSF12 by ELISA at 1:1562500. TNFSF12 antibody can be used for detection of TNFSF12 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
- Park, M.C., (2008) Scand. J. Rheumatol. 37 (3), 173-178.
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
batch dependent
Unconjugated
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TNFSF12.
8742
tumor necrosis factor (ligand) superfamily, member 12
TNFSF12
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
17 kDa
NP_003800
4507597
Antibody is purified by peptide affinity chromatography method.
Membrane ,Cancer ,Signal Transduction ,Immunology ,Primary ///Apoptosis ,
O43508
Optimal dilutions for each application to be determined by the researcher.