ProSci

REST Antibody

Product Code:
 
PSI-79-672
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store antibody at -20˚C for up to one year.
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Western blot analysis of extract from HeLa cells using REST Antibody.
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Western blot analysis of extract from HeLa cells using REST Antibody.

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PSI-79-672-0.1mg0.1mg£481.00
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Further Information

Additional Names:
XBR, NRSF, RNF53, XBR, REST
Application Note:
Western Blot: 1:500~1:1000
Background:
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
Background References:
  • Chong J. A. et. al. (1995) Cell 80:949-957Schoenherr C. J. et. al. (1995) Science 267:1360-1363Scholl T. et. al. (1996) J. Immunol. 156:1448-1457Lunyak V. V. et. al. (2002) Science 298:1747-1752
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
REST antibody was raised against a peptide sequence around aa.873~877 (R-E-E-A-S) derived from Human REST.
NCBI Gene ID #:
5978
NCBI Official Name:
RE1-silencing transcription factor
NCBI Official Symbol:
REST
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
121 kDa
Protein Accession #:
NP_001180437.1
Protein GI Number:
301897977
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Stem Cell
SPECIFICITY:
This antibody detects endogenous level of total REST protein.
Swissprot #:
Q13127