Further Information
GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16, CD61 antigen, ITB3, Platelet membrane glycoprotein IIIa
Western Blot: 1:500~1:1000
The Itg-Beta3 gene encodes the beta subunit of the platelet membrane adhesive protein receptor complex Itg-Beta3 protein, which belongs to the Integrin class of cell adhesion molecule receptors that share a common heterotrimeric structure with Alpha and Beta subunits. It is a common Beta subunit of the platelet complex and of two other Integrins (Fibronectin and Vitronectin Receptors), which have distinct Alpha subunits. Itg-Beta3 has been implicated in a wide variety of functions, including platelet aggregation and thrombosis and implantation, placentation, angiogenesis, bone remodeling, and tumor progression. Glanzmann Thrombasthenia can result from defects in the genes for either the Itg-Alpha2B or the Itg-Beta3 subunit
- Sujoy Bhattacharya, et al. (2006) Biochem J. August 1; 397 (Pt 3): 437?447Courter DL, et al. (2005) J Biol Chem Apr 01; 280 (13): 12145-12151Chandhoke SK, et al. (2004) J Cell Sci Mar 15; 117 (Pt 8): 1431-1441
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Integrin beta3 (Ab-785) antibody was raised against a peptide sequence around aa.783~787 (I-T-Y-R-G) derived from Human Integrin B3/ITGB3.
3690
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB3
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
110 kDa
NP_000203.2
47078292
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Other
This antibody detects endogenous level of total Integrin β3 protein.
P05106