ProSci

DNA PKcs Antibody

Product Code:
 
PSI-79-568
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store antibody at -20˚C for up to one year.
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Western blot analysis of lysed extracts from HT29 and HepG2 cells using DNA PKcs (Ab-2609).
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Western blot analysis of lysed extracts from HT29 and HepG2 cells using DNA PKcs (Ab-2609).

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PSI-79-568-0.1mg0.1mg£481.00
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Further Information

Additional Names:
HYRC, p350, DNAPK, DNPK1, HYRC1, XRCC7, DNA-PKcs, EPLG5, HTKL, LERK5, PRKD, PRKDC, P460
Application Note:
Western Blot: 1:500~1:1000
Background:
The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties
Background References:
  • Chan DW, et al. (2002) Genes Dev. Sep 15; 16 (18): 2333-2338Ding Q, et al. (2003) Mol Cell Biol. Aug; 23 (16): 5836-5848Douglas P, et al. (2002) Biochem J. Nov 15; 368 (Pt 1): 243-251
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
DNA PKcs (Ab-2609) antibody was raised against a peptide sequence around aa.2607~2611 (V-E-T-Q-A) derived from Human DNA-PK.
NCBI Gene ID #:
5591
NCBI Official Name:
protein kinase, DNA-activated, catalytic polypeptide
NCBI Official Symbol:
PRKDC
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
450 kDa
Protein Accession #:
NP_001075109.1
Protein GI Number:
126032350
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Cell Cycle
SPECIFICITY:
This antibody detects endogenous level of total DNA PKcs protein.
Swissprot #:
P78527