ProSci

BCL-XL Antibody

Product Code:
 
PSI-79-525
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Storage:
 
Store antibody at -20˚C for up to one year.
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Western blot analysis of lysed extracts from 293 and HeLa cells using BCL-XL (Ab-62).
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Western blot analysis of lysed extracts from 293 and HeLa cells using BCL-XL (Ab-62).

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PSI-79-525-0.1mg0.1mg£481.00
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Further Information

Additional Names:
BCLX, BCL2L, BCLXL, BCLXS, Bcl-X, bcl-xL, bcl-xS, PPP1R52, BCL-XL/S, P53, Apoptosis regulator Bcl-X
Application Note:
Western Blot: 1:500~1:1000
Background:
Potent inhibitor of cell death. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases By similarity. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.
Background References:
  • Basu A, et. al. ( 2003) Mar 13; 538 (1-3): 41-7Cheng E. H. -Y. et. al. (1996) Nature 379:554-556. Sattler M. et. al. (1997) , Science 275:983-986. Muchmore S. W. et. al (1996) . Nature 381:335-341Yu J., Zhang L. Mol. (2001) Cell 7:673-682
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
BCL-XL (Ab-62) antibody was raised against a peptide sequence around aa.60~64 (A-D-S-P-A) derived from human BCL-XL .
NCBI Gene ID #:
598
NCBI Official Name:
BCL2-like 1
NCBI Official Symbol:
BCL2L1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
30 kDa
Protein Accession #:
NP_612815.1
Protein GI Number:
20336335
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Apoptosis,Cancer
SPECIFICITY:
This antibody detects endogenous level of total BCL-XL protein.
Swissprot #:
Q07817