ProSci

TARDBP Antibody

Product Code:
 
PSI-28-975
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Canine (dog)
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
 
For short periods of storage (days) store at 4˚C. For longer periods of storage, store TARDBP antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
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Antibody used in IHC on Human Liver.
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3 / 4
Antibody used in WB on Human HepG2 at 1.25 ug/ml.
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Antibody used in WB on HepG2 at 1.25 ug/ml (Lane A: Primary Antibody and Lane B: Primary Antibody + Blocking Peptide ).
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Antibody used in IHC on Human Liver.
Antibody used in WB on Human HepG2 at 1.25 ug/ml.
Antibody used in WB on HepG2 at 1.25 ug/ml (Lane A: Primary Antibody and Lane B: Primary Antibody + Blocking Peptide ).

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PSI-28-975-100ul100ul£609.00
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Further Information

Additional Names:
TARDBP, ALS10, TDP-43
Application Note:
TARDBP antibody can be used for detection of TARDBP by ELISA at 1:1562500. TARDBP antibody can be used for detection of TARDBP by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Background:
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. TARDBP is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription.HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
Background References:
  • Buratti, E., (2005) J. Biol. Chem. 280 (45), 37572-37584.
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TARDBP.
NCBI Gene ID #:
23435
NCBI Official Name:
TAR DNA binding protein
NCBI Official Symbol:
TARDBP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
45 kDa
Protein Accession #:
NP_031401
Protein GI Number:
6678271
Purification:
Antibody is purified by protein A chromatography method.
Research Area:
Transcription ,RNA Binding ,Cell Cycle
Swissprot #:
Q13148
User NOte:
Optimal dilutions for each application to be determined by the researcher.