Further Information
MAPK14, RK, p38, CSBP, EXIP, Mxi2, CSBP1, CSBP2, CSPB1, PRKM14, PRKM15, SAPK2A, p38ALPHA
MAPK14 antibody can be used for detection of MAPK14 by ELISA at 1:1562500. MAPK14 antibody can be used for detection of MAPK14 by western blot at 0.625 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
- Choi, S.Y., et al., (2006) J. Biol. Chem. 281 (11), 7049-7059.
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
batch dependent
Unconjugated
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MAPK14.
1432
mitogen-activated protein kinase 14
MAPK14
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
41 kDa, 41 kDa
NP_001306
4503069
Antibody is purified by protein A chromatography method.
Transcription ,Cancer
Q16539
Optimal dilutions for each application to be determined by the researcher.