Further Information
HD4, AHO3, BDMR, HDACA, HA6116, HDAC-4, HDAC-A, AML1, CBFA2, HD4
Western Blot: 1:500~1:1000
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.
- Wang AH, et al. (2000) Mol Cell Biol. 20 (18): 6904-6912. Grozinger CM, et al. (2000) Proc Natl Acad Sci U S A. 97 (14): 7835-7840.
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
HDAC4 (Phospho-Ser632) antibody was raised against a peptide sequence around phosphorylation site of serine 632 (A-Q-S (p) -S-P) derived from Human HDAC4.
Phospho-Specific
9759
histone deacetylase 4
HDAC4
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
140 kDa
NP_006028.2
153085395
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Phospho-Specific,Cell Cycle
This antibody detects endogenous level of HDAC4 only when phosphorylated at serine 632.
P56524