ProSci

Rab 3 Antibody

Product Code:
 
PSI-50-188
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Bovine (Cattle)
  • Canine (dog)
  • Human
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Storage:
 
Rab 3 antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
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Western blot of rat cortex lysate showing specific immunolabeling of the ~82k rabphilin 3A.
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Western blot of rat cortex lysate showing specific immunolabeling of the ~82k rabphilin 3A.

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PSI-50-188-0.1mL0.1mL£686.00
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This product comes from: United States.
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Further Information

Background:
Rabphilin-3A is a peripheral membrane protein that binds Ca2+ and phospholipids and is attached to synaptic vesicle membranes (Geppert et al., 1994;Li et al., 1994). The expression of rabphilin 3A is reduced in an animal model of Huntington?s disease (Smith et al., 2005). Rabphilin can be phosphorylated at Ser234 by both CAM kinase II and PKA and this phosphorylation has been suggested to regulate neuronal activity during development in a synapse-specific manner (Fykse et al., 1995;Foletti and Scheller, 2001).
Background References:
  • Foletti DL, Scheller RH (2001) Developmental regulation and specific brain distribution of phosphorabphilin. J Neurosci 21:5461-5472.
  • Fykse EM, Li C, Sudhof TC (1995) Phosphorylation of rabphilin-3A by Ca2+/calmodulin- and cAMP-dependent protein kinases in vitro. J Neurosci 15:2385-2395.
  • Geppert M, Bolshakov VY, Siegelbaum SA, Takei K, De Camilli P, Hammer RE, S?dhof TC (1994) The role of Rab3A in neurotransmitter release. Nature (Lond ) 369:493-497.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide corresponding to amino acid residues from the C-terminal region of rabphilin 3A.
NCBI Gene ID #:
171039
NCBI Official Name:
rabphilin 3A
NCBI Official Symbol:
Rph3a
NCBI Organism:
Rattus norvegicus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
82
Protein Accession #:
P47709
Protein GI Number:
1350830
Purification:
Affinity Purified
Swissprot #:
P47709
User NOte:
Optimal dilutions for each application to be determined by the researcher.