ProSci

TGFBR2 Antibody

Product Code:
 
PSI-31-354
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
For short periods of storage (days) store at 4˚C. For longer periods of storage, store TGFBR2 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
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Antibody used in WB on Human HepG2 cells at 5.0 ug/ml.
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Antibody used in WB on Human HepG2 cells at 5.0 ug/ml.

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PSI-31-354-100ul100ul£609.00
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Further Information

Additional Names:
TGFBR2, HNPCC6, MFS2, RIIC, Tbeta, AAT3, FAA3, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII
Application Note:
TGFBR2 antibody can be used for detection of TGFBR2 by ELISA at 1:312500. TGFBR2 antibody can be used for detection of TGFBR2 by western blot at 5.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Background:
TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in its gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors.This gene is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It encodes a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein and binds TGF-beta. This receptor/ligand complex phosphorylates proteins which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Background References:
  • Song, K., (2006) J. Biol. Chem. 281 (12), 7765-7774.
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TGFBR2.
NCBI Gene ID #:
7048
NCBI Official Name:
transforming growth factor, beta receptor II (70/80kDa)
NCBI Official Symbol:
TGFBR2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
62 kDa, 67 kDa
Protein Accession #:
NP_003233
Protein GI Number:
67782324
Purification:
Antibody is purified by protein A chromatography method.
Research Area:
Membrane ,Cancer
Swissprot #:
P37173
User NOte:
Optimal dilutions for each application to be determined by the researcher.