ProSci

Neurofilament NF-L Antibody

Product Code:
 
PSI-50-256
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Chicken
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Avian
  • Bovine (Cattle)
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
 
Neurofilament NF-L antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
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Western blot of rat cortex lysate showing specific immunolableing of the ~ 68k NF-L protein.
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Western blot of rat cortex lysate showing specific immunolableing of the ~ 68k NF-L protein.

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PSI-50-256-0.1mL0.1mL£626.00
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This product comes from: United States.
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Further Information

Background:
Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-L is the neurofilament light or low molecular weight polypeptide and runs on SDS-PAGE gels at about 68 kDa. Antibodies to NF-L are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. Mutations in the protein coding region of the human NF-L gene cause some forms of Charcot-Marie-Tooth disease.
Background References:
  • Harris, J., Ayyub, C. and Shaw G. (1991) A molecular dissection of the carboxyterminal tails of the major neurofilament subunits NF-M and NF-H. J Neurosci Res 30:47-62.
  • Mersiyanova IV, Perepelov AV, Polyakov AV, Sitnikov VF, Dadali EL, Oparin RB, Petrin AN and Evgrafov OV. (2000) A new variant of Charcot-Marie-Tooth disease type 2 is probably the result of a mutation in the neurofilament-light gene. Am. J. Hum. Genet. 67:37-46.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Preparation of bovine spinal cord intermediate filaments
NCBI Gene ID #:
4747
NCBI Official Name:
neurofilament, light polypeptide
NCBI Official Symbol:
NEFL
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
68
Protein Accession #:
P07196
Protein GI Number:
62511894
Purification:
Total IgY fraction
Research Area:
Neuroscience
SPECIFICITY:
Specific for the ~68k Neurofilament L protein in Western blots and works well on frozen sections, cells in tissue culture and on mildly formalin fixed histological sections.
Swissprot #:
P07196
User NOte:
Optimal dilutions for each application to be determined by the researcher.