(+)-Catechin . hydrate

AdipoGen Life Sciences
Product Code: AG-CN2-0407

CodeSizePrice
AG-CN2-0407-M500500 mg£35.00
Quantity:
AG-CN2-0407-G0011 g£50.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C

Images

1 / 1
Chemical Structure

Chemical Structure

Further Information

Alternate Names/Synonyms:
Cianidanol; Cyanidol; Catechol; Catechuic acid; NSC 2819; (+)-3,3',4',5,7-Flavanpentol
Appearance:
Off-white powder.
CAS:
225937-10-0 or 88191-48-4
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry.Keep under inert gas.Protect from light.
Hazards:
H315, H319, H335
InChi:
InChI=1S/C15H14O6.H2O/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7;/h1-5,13,15-20H,6H2;1H2/t13-,15+;/m0./s1
InChiKey:
OFUMQWOJBVNKLR-NQQJLSKUSA-N
Long Description:
Chemical. CAS: 225937-10-0 or 88191-48-4. Formula: C15H14O6 . H2O. MW: 290.3 . 18.0. Isolated from Uncaria rhynchophylla. Specific histidine decarboxylase inhibitor. Anti-inflammatory. COX-1 inhibitor. Antioxidant flavonoid. Free radical scavenger. Inhibits lipid peroxidation. Antimetastatic and anticancer compound. Antiangiogenic. Anti-osteoporotic. Antibacterial and antifungal. Neuroprotective. Mono oxidase B inhibitor. Apoptosis and cell cycle arrest inducer. JNK phosphorylation inhibitor. Antispasmodic. Insulin-mimetic.
MDL:
MFCD00150865
Molecular Formula:
C15H14O6 . H2O
Molecular Weight:
290.3 . 18.0
Package Type:
Vial
Precautions:
P261, P280, P302, P352, P304, P340, P405
Product Description:
Specific histidine decarboxylase inhibitor [1]. Anti-inflammatory. COX-1 inhibitor [2]. Antioxidant flavonoid. Free radical scavenger. Inhibits lipid peroxidation [3, 6, 9]. Antimetastatic and anticancer compound [4, 9, 10, 14, 16, 17]. Antiangiogenic [14]. Anti-osteoporotic [5]. Antibacterial and antifungal [7]. Neuroprotective [8]. Mono oxidase B inhibitor [11]. Apoptosis and cell cycle arrest inducer [9, 10, 16, 17]. JNK phosphorylation inhibitor [12]. Antispasmodic [13]. Insulin-mimetic [15].
Purity:
>95% (NMR)
Signal word:
Warning
SMILES:
O.O[C@H]1CC2=C(O)C=C(O)C=C2O[C@@H]1C1=CC=C(O)C(O)=C1
Solubility Chemicals:
Soluble in DMSO, ethanol or dimethylformamide. Sparingly soluble in water.
Source / Host:
Isolated from Uncaria rhynchophylla or Camellia sinensis.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C. After reconstitution, prepare aliquots and store at -20°C.

References

Histamine and acute haemorrhagic lesions in rat gastric mucosa: prevention of stress ulcer formation by (+)-catechin, an inhibitor of specific histidine decarboxylase in vitro: H.J. Reimann, et al.; Agents Actions 7, 69 (1977) | Flavan-3-ols isolated from some medicinal plants inhibiting COX-1 and COX-2 catalysed prostaglandin biosynthesis: Y. Noreen, et al.; Planta Med. 64, 520 (1998) | (+)-Catechin as antioxidant: mechanisms preventing human plasma oxidation and activity in red wines: S.B. Lotito & C.G. Fraga; Biofactors 10, 125 (1999) | Flavonoids as anticancer agents: structure-activity relationship study: M. Lopez-Lazaro; Curr. Med. Chem. Anticancer Agents 2, 691 (2002) (Review) | Effects of (+)-catechin on the function of osteoblastic cells: E.M. Choi & J.K. Hwang; Biol. Pharm. Bull. 26, 523 (2003) | Dietary supplementation of (+)-catechin protects against UVB-induced skin damage by modulating antioxidant enzyme activities: S.E. Jeon, et al.; Photodermatol. Photoimmunol. Photomed. 19, 235 (2003) | Phytotoxic and antimicrobial activities of catechin derivatives: R. Veluri, et al.; J. Agric. Food Chem. 52, 1077 (2004) | Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases: S. Mandel & M.B. Youdim; Free Radic. Biol. Med. 37, 304 (2004) (Review) | A green tea component, catechin, rapidly induces apoptosis of myeloid leukemic cells via modulation of reactive oxygen species production in vitro and inhibits tumor growth in vivo: L. Gordon; Haematologica 90, 290 (2005) | (+)-Catechin, an ingredient of green tea, protects murine microglia from oxidative stress-induced DNA damage and cell cycle arrest: Q. Huang, et al.; J. Pharmacol. Sci. 98, 16 (2005) | Monoamine oxidase B (MAO-B) inhibition by active principles from Uncaria rhynchophylla: W.C. Hou; J. Ethnopharmacol. 100, 216 (2005) | (+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation: W.B. Wu, et al.; Life Sci. 79, 801 (2006) | Antispasmodic, bronchodilator and vasodilator activities of (+)-catechin, a naturally occurring flavonoid: M.N. Ghayur, et al.; Arch. Pharm. Res. 30, 970 (2007) | (+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-alpha in LPS-stimulated macrophages: C. Guruvayoorappan & G. Kuttan; Innate Immun. 14, 160 (2008) | Insulin mimetic impact of Catechin isolated from Cassia fistula on the glucose oxidation and molecular mechanisms of glucose uptake on Streptozotocin-induced diabetic Wistar rats: P. Daisy, et al.; Phytomedicine 17, 28 (2010) | Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis: A.A. Alshatwi; J. Exp. Clin. Cancer Res. 29, 167 (2010) | Catechin hydrate inhibits proliferation and mediates apoptosis of SiHa human cervical cancer cells: A.A. Al-Hazzani & A.A. Alshatwi; Food Chem. Toxicol. 49, 3281 (2011)