AdipoGen Life Sciences

6-Aminophenanthridine

Product Code:
 
AG-MR-C0029
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
-20°C
Storage:
 
-20°C
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Chemical Structure
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Chemical Structure

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Further Information

Alternate Names/Synonyms:
6AP
Appearance:
Beige solid.
CAS:
832-68-8
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.
Hazards:
H319
InChi:
InChI=1S/C13H10N2/c14-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)15-13/h1-8H,(H2,14,15)
InChiKey:
FVCXJXKLDUJOFA-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 832-68-8. Formula: C13H10N2. MW: 194.2. Antiprion agent. Ribosome-borne protein folding activity (RPFA) inhibitor. Binds to the ribosomal RNA and inhibits specifically the protein folding activity of the ribosome. Inhibitor of protein aggregation.
MDL:
MFCD01708752
Molecular Formula:
C13H10N2
Molecular Weight:
194.2
Package Type:
Vial
Precautions:
P280, P305, P351, P338
Product Description:
Antiprion agent. Ribosome-borne protein folding activity (RPFA) inhibitor. Binds to the ribosomal RNA and inhibits specifically the protein folding activity of the ribosome. Inhibitor of protein aggregation.
Purity:
>97% (HPLC)
Signal word:
Warning
SMILES:
NC1=NC2=C(C=CC=C2)C2=C1C=CC=C2
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

An expeditious synthesis of 6-aminophenanthridines: F. Gug, et al.; THL 46, 3725 (2005) | Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs: D. Tribouillard-Tanvier, et al.; PLoS One 3, e2174 (2008) | Tools for the study of ribosome-borne protein folding activity: C. Voisset, et al.; Biotechnol. J. 3, 1033 (2008) | Mode of action of the antiprion drugs 6AP and GA on ribosome assisted protein folding: S.D. Reis, et al.; Biochimie 93, 1047 (2011) | Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy: N. Barbezier, et al.; EMBO Mol. Med. 3, 35 (2011) | The antiprion compound 6-aminophenanthridine inhibits the protein folding activity of the ribosome by direct competition: Y. Pang, et al.; J. Biol. Chem. 288, 19081 (2013)