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This product comes from:
Switzerland.
Typical lead time:
7-10 working days.
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Further Information
Light red powder.
19088-73-4
32160000
liquid
GHS07
Protect from light and moisture.
H302, H312, H315, H319, H332, H335
InChI=1S/C10H5NO3/c11-5-7-3-6-1-2-8(12)4-9(6)14-10(7)13/h1-4,12H
IJQYTHQDUDCJEQ-UHFFFAOYSA-N
Chemical. CAS: 19088-73-4. Formula: C10H5NO3. MW: 187.15. Synthetic. Phenolic dyes with high pKas - such as 7-hydroxycoumarin (often called umbelliferone) and the more common 7-hydroxy-4-methylcoumarin - are not fully deprotonated and therefore not fully fluorescent unless the pH of the reaction mixture is raised to above pH ~10. Thus, substrates derived from these fluorophores are seldom used for continuous measurement of enzymatic activity in solution or live cells. The similar 3-cyano-7-hydroxycoumarin and 6,8-difluoro-7-hydroxy-4-methylcoumarin have lower pKas, making them suitable for a broader range of applications. Moreover, the -trifluoromethylumbelliferone product has longer-wavelength spectra and stronger absorbance than -methylumbelliferone. Ether, ester and phosphate substrates derived from these phenolic dyes may be fluorescent but invariably exhibit shorter-wavelength absorption and emission spectra.
MFCD00037480
C10H5NO3
187.15
Vial
P261, P280, P305, P351, P338
Phenolic dyes with high pKas - such as 7-hydroxycoumarin (often called umbelliferone) and the more common 7-hydroxy-4-methylcoumarin - are not fully deprotonated and therefore not fully fluorescent unless the pH of the reaction mixture is raised to above pH ~10. Thus, substrates derived from these fluorophores are seldom used for continuous measurement of enzymatic activity in solution or live cells. The similar 3-cyano-7-hydroxycoumarin and 6,8-difluoro-7-hydroxy-4-methylcoumarin have lower pKas, making them suitable for a broader range of applications. Moreover, the -trifluoromethylumbelliferone product has longer-wavelength spectra and stronger absorbance than -methylumbelliferone. Ether, ester and phosphate substrates derived from these phenolic dyes may be fluorescent but invariably exhibit shorter-wavelength absorption and emission spectra.
>98% (TLC)
Warning
OC1=CC=C2C=C(C#N)C(=O)OC2=C1
Soluble in alcohols or DMF.
Synthetic.
Non-hazardous
Fluorescent Reagents
41105331
Stable for at least 2 years after receipt when stored at +4°C.