ProSci

GLIPR1 Antibody

Product Code:
 
PSI-7623
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
1 / 2
Western blot analysis of GLIPR1 in human small intestine tissue lysate with GLIPR1 antibody at 1 μg/ml.
2 / 2
Immunoflorescence of GLIPR1 in human small intestine tissue with GLIPR1 antibody at 5 μg/mL.
❮❯

Western blot analysis of GLIPR1 in human small intestine tissue lysate with GLIPR1 antibody at 1 μg/ml.
Immunoflorescence of GLIPR1 in human small intestine tissue with GLIPR1 antibody at 5 μg/mL.

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CodeSizePrice
PSI-7623-0.02mg0.02mg£150.00
Quantity:
PSI-7623-0.1mg0.1mg£449.00
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Further Information

Additional Names:
GLIPR1 Antibody: GLIPR, RTVP1, CRISP7, GLIPR, Glioma pathogenesis-related protein 1, Protein RTVP-1, GliPR 1
Application Note:
GLIPR1 antibody can be used for detection of GLIPR1 by Western blot at 1 - 2 μg/ml. For Immunoflorescence start at 5 μg/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
The glioma pathogensis-related protein 1 (GLIPR1) is similar to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family (1). GLIPR1 is a tumor suppressor whose expression is regulated by p53; its increased expression is associated with myelomocytic differentiation in macrophages, whereas decreased expression of this gene through gene methylation is associated with prostate cancer (2). The GLIPR1 gene is part of a p53 target gene cluster that includes GLIPR1L1 and GLIPR1L2, two highly homologous proteins whose expression patterns vary (3).
Background References:
  • Murphy EV, Zhang Y, Zhu W, et al. The human glioma pathogenesis-related protein is structurally related to pathogenesis-related proteins and its gene is expressed specifically in brain tumors. Gene 1995; 159:131-5.
  • Ren C, Li L, Yang G, et al. RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer. Cancer Res. 2004; 64:969-76.
  • Ren C, Ren CH, Li L, et al. Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. Genomics 2006; 88:163-72.
Buffer:
GLIPR1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
GLIPR1 antibody was raised against an 18 amino acid peptide near the center of human GLIPR1.

The immunogen is located within amino acids 60 - 110 of GLIPR1.
NCBI Gene ID #:
11010
NCBI Official Name:
GLI pathogenesis-related 1
NCBI Official Symbol:
GLIPR1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 29 kDa

Observed: 29 kDa
Protein Accession #:
NP_006842
Protein GI Number:
110825980
Purification:
GLIPR1 antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
SPECIFICITY:
GLIPR1 antibody is human and mouse reactive. At least two isoforms of GLIPR1 are known to exist; this antibody will detect both isoforms. This antibody is predicted to not cross-react with other GLIPR or GLIPR-like proteins.
Swissprot #:
P48060
User NOte:
Optimal dilutions for each application to be determined by the researcher.