ProSci

CXCL12 Antibody

Product Code:
 
PSI-7591
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
1 / 2
Western blot analysis of CXCL12 in HeLa cell lysate with CXCL12 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
2 / 2
Immunocytochemistry of CXCL12 in HeLa cells with CXCL12 antibody at 5 μg/mL.
❮❯

Western blot analysis of CXCL12 in HeLa cell lysate with CXCL12 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Immunocytochemistry of CXCL12 in HeLa cells with CXCL12 antibody at 5 μg/mL.

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CodeSizePrice
PSI-7591-0.02mg0.02mg£150.00
Quantity:
PSI-7591-0.1mg0.1mg£449.00
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Further Information

Additional Names:
CXCL12 Antibody: IRH, PBSF, SDF1, TLSF, TPAR1, SCYB12, SDF1A, SDF1B, Stromal cell-derived factor 1, C-X-C motif chemokine 12, SDF-1
Application Note:
CXCL12 antibody can be used for detection of CXCL12 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunocytochemistry starting at 5 μg/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.
Background:
The CXCL12 protein, also known as SDF1, is a stromal cell-derived alpha chemokine member of the intercrine family. CXCL12 functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4 (CXCR4) and CXCR7, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis (reviewed in 1). Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections (2).
Background References:
  • Timotijevic G, Mostarica Stojkovic M, and Miljkovic D. CXCL12: role in neuroinflammation. Int. J. Biochem. Cell Biol. 2012; 44:838-41.
  • Reiche EM, Ehara Watanabe MA, Bonametti AM, et al. The effect of stromal cell-derived factor 1 (SDF1/CXCL12) genetic polymorphism on HIV-1 disease progression. Int. J. Mol. Med. 2006; 18:785-93.
Buffer:
CXCL12 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CXCL12 antibody was raised against a 16 amino acid peptide near the center of human CXCL12 .

The immunogen is located within the last 50 amino acids of CXCL12.
NCBI Gene ID #:
6387
NCBI Official Name:
chemokine (C-X-C motif) ligand 12
NCBI Official Symbol:
CXCL12
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 15 kDa

Observed: 18 kDa
Protein Accession #:
NP_001171605
Protein GI Number:
296011023
Purification:
CXCL12 antibody is affinity chromatography purified via peptide column.
Research Area:
Immunology
SPECIFICITY:
CXCL12 antibody is human and mouse reactive. Multiple isoforms of CXCL12 are known to exist.
Swissprot #:
P48061
User NOte:
Optimal dilutions for each application to be determined by the researcher.