ProSci

IL-36RN Antibody

Product Code:
 
PSI-7511
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
1 / 3
Western blot analysis of IL-36RN in human spleen tissue lysate with IL-36RN antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
2 / 3
Immunohistochemistry of IL-36RN in rat small intestine tissue with IL-36RN antibody at 5 μg/mL.
3 / 3
Immunofluorescence of IL-36RN in rat small intestine tissue with IL-36RN antibody at 20 μg/mL.
❮❯

Western blot analysis of IL-36RN in human spleen tissue lysate with IL-36RN antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry of IL-36RN in rat small intestine tissue with IL-36RN antibody at 5 μg/mL.
Immunofluorescence of IL-36RN in rat small intestine tissue with IL-36RN antibody at 20 μg/mL.

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CodeSizePrice
PSI-7511-0.02mg0.02mg£150.00
Quantity:
PSI-7511-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
IL-36RN Antibody: FIL1, FIL1D, IL1F5, IL1L1, PSORP, IL1HY1, IL1RP3, IL36RA, FIL1(DELTA), UNQ1896/PRO4342, Interleukin-36 receptor antagonist protein, FIL1 delta, IL-1RP3
Application Note:
IL-36RN antibody can be used for detection of IL-36RN by Western blot at 1 μg/ml.

Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Background:
IL-36RN is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 (1). IL-36RN specifically inhibits the activation of NF-kappaB induced IL-36A (2). The opposing activities of these cytokines have been suggested to be involved in the regulation of skin inflammation (3). Like the IL-36 cytokines (IL-36A, IL-36B and IL-36G), IL-36RN requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown (4).
Background References:
  • Smith DE, Renshaw BR, Ketchem RR, et al. Four new members expand the interleukin-1 superfamily. J. Biol. Chem. 2000; 275:1169-75.
  • Debets R, Timans JC, Homey B, et al. Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. J. Immunol. 2001; 167:1440-6.
  • Blumberg H, Dinh H, Trueblood ES, et al. Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation. J. Exp. Med. 2007; 204:2603-14.
  • Towne JE, Renshaw BR, Douangpanya J, et al. Interleukin-36 (IL-36) ligands require processing for full agonist agonist (IL-36a, IL-36b, and IL-36g) or antagonist (IL-36Ra) activity. J. Biol. Chem. 2011; 286:42594-602.
Buffer:
IL-36RN antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
IL-36RN antibody was raised against a 19 amino acid peptide near the carboxy terminus of human IL-36RN.

The immunogen is located within the last 50 amino acids of IL-36RN.
NCBI Gene ID #:
26525
NCBI Official Name:
interleukin 36 receptor antagonist
NCBI Official Symbol:
IL36RN
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed Molecular Weight: 24 kDa
Protein Accession #:
NP_775262
Protein GI Number:
27894310
Purification:
IL-36RN antibody is affinity chromatography purified via peptide column.
Research Area:
Immunology
SPECIFICITY:
IL-36RN antibody is human and mouse reactive. At least two isoforms of IL-36RN are known to exist
Swissprot #:
Q9UBH0
User NOte:
Optimal dilutions for each application to be determined by the researcher.