ProSci

WDR18 Antibody

Product Code:
 
PSI-6817
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
1 / 2
Western blot analysis of WDR18 in rat lung tissue lysate with WDR18 antibody at (A) 1 and (B) 2 μg/mL.
2 / 2
Immunohistochemistry of WDR18 in human lung tissue with WDR18 antibody at 2.5 μg/mL.
❮❯

Western blot analysis of WDR18 in rat lung tissue lysate with WDR18 antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of WDR18 in human lung tissue with WDR18 antibody at 2.5 μg/mL.

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CodeSizePrice
PSI-6817-0.02mg0.02mg£150.00
Quantity:
PSI-6817-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
WDR18 Antibody: Ipi3, R32184_1, WD repeat-containing protein 18
Application Note:
WDR18 antibody can be used for detection of WDR18 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 2.5 μg/mL.

Antibody validated: Western Blot in rat samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Background:
WDR18 Antibody: WD repeat domain 18 (WDR18) is a member of the WD repeat protein family, which is involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WD repeats are minimally conserved regions of approximately 40 amino acids that commonly form a tertiary propeller structure. WDR18 is a 432 amino acid protein that contains six WD repeats and is encoded by a gene located on human chromosome 19. WDR18 may play a role during development. The complex PELP1-TEX10-WDR18 is required for the maturation and nucleolar release of the large ribosomal subunit.
Background References:
  • Smith TF, Gaitatzes C, Saxena K, et al. The WD repeat: a common architecture for diverse functions. Trends Biochem. Sci. 1999; 24:181-5.
  • Gao W, Xu L, Guan R, et al. Wdr18 is required for Kupffer's vesicle formation and regulation of body asymmetry in zebrafish. PLoS One 2011; 6:e23386.
  • Finkbeiner E, Haindl M, and Muller S. The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex. EMBO J. 2011; 30:1067-78.
Buffer:
WDR18 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen:
WDR18 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human WDR18.

The immunogen is located within the last 50 amino acids of WDR18.
NCBI Gene ID #:
57418
NCBI Official Name:
WD repeat domain 1
NCBI Official Symbol:
WDR18
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_077005
Protein GI Number:
56243583
Purification:
WDR18 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
WDR18 antibody is predicted to not cross-react with other WDR family members.
Swissprot #:
Q9BV38
User NOte:
Optimal dilutions for each application to be determined by the researcher.